HCID 22291207、化合物 → tert-Butyl 1,7-diazaspiro[4.4]nonane-7-carboxylate

HRID 2076399ノート

反応式

HRID 2076399 の反応式
C([N:8]1[CH2:23][CH2:22][CH2:21][C:9]21[CH2:13][N:12]([C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15])[CH2:11][CH2:10]2)C1C=CC=CC=1>CO.[Pd]>[CH2:13]1[C:9]2([CH2:21][CH2:22][CH2:23][NH:8]2)[CH2:10][CH2:11][N:12]1[C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15]

参加物

4

反応物 1

HCID 22291207HCID 22291207、化合物

生成物 1

HCID 22291199tert-Butyl 1,7-diazaspiro[4.4]nonane-7-carboxylate収率 100%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

A solution of t-butyl 6-benzyl-2,6-diazaspiro[4.4]nonane-2-carboxylate (1.70 g, 5.37 mmol) in methanol (30 mL) was mixed with 10% palladium on carbon (50 mg). The mixture was shaken under a hydrogen atmosphere (50 psi) in a Parr hydrogenation apparatus for 8 h and filtered through Celite. The filtrate was concentrated by rotary evaporation and high vacuum treatment, leaving 1.26 g of viscous, light brown oil (>100%), which was of sufficient purity to be used in the subsequent reaction.

後処理

  1. filtrationfiltered through Celite
  2. concentrationThe filtrate was concentrated by rotary evaporation and high vacuum treatment

出典と根拠

ORDレコード
ord-36f23253111147049028ec2887709e11
出典データセット
uspto-grants-2011_04
特許番号
US07923559B2

反応ノート

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