Thionyl Chloride → HCID 86629256、化合物

HRID 2078099ノート

反応式

HRID 2078099 の反応式
[I:1][C:2]1[C:10]([C:11]([F:14])([F:13])[F:12])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4](O)=[O:5].S(Cl)([Cl:17])=O>>[I:1][C:2]1[C:10]([C:11]([F:14])([F:13])[F:12])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([Cl:17])=[O:5]

参加物

3

反応物 2

HCID 24386Thionyl ChlorideHCID 146125442-Iodo-3-(trifluoromethyl)benzoic acid

生成物 1

HCID 86629256HCID 86629256、化合物収率 99.4%

実験手順

2-Iodo-3-(trifluoromethyl)benzoic acid (10.0 g, 31.6 mmol) was stirred in thionyl chloride (100 mL, 31.6 mmol) at reflux for 2 hours. The mixture was then cooled to room temperature. The thionyl chloride was removed under vacuum, and the residue was azeotroped with dry toluene to give the product as a yellow-orange semi-solid (10.51 g).

後処理

  1. temperatureat reflux for 2 hours
  2. customThe thionyl chloride was removed under vacuum
  3. customthe residue was azeotroped with dry toluene

出典と根拠

ORDレコード
ord-88fb862b1861477d87bc2e28705c6ec1
出典データセット
uspto-grants-2011_04
特許番号
US07928139B2

反応ノート

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