HCID 67100256、化合物 → HCID 57983375、化合物

HRID 2078213ノート

反応式

HRID 2078213 の反応式
[OH:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[CH:10]=2)[C:5]2([CH2:21][CH2:20][CH2:19][CH2:18]2)[C:4](=[O:22])[C:3]=1[C:23]([NH:25][CH2:26][C:27]([O:29]C(C)(C)C)=[O:28])=[O:24]>C(O)(C(F)(F)F)=O.CCOCC>[OH:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([C:12]3[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=3)[CH:10]=2)[C:5]2([CH2:21][CH2:20][CH2:19][CH2:18]2)[C:4](=[O:22])[C:3]=1[C:23]([NH:25][CH2:26][C:27]([OH:29])=[O:28])=[O:24]

参加物

4

反応物 1

HCID 67100256HCID 67100256、化合物

生成物 1

HCID 57983375HCID 57983375、化合物収率 20.9%

試薬・触媒・溶媒 2

HCID 3283Diethyl Ether溶媒HCID 6422Trifluoroacetic acid溶媒

実験手順

1,1-Dimethylethyl N-((4′-hydroxy-2′-oxo-6′-phenyl-spiro[cyclopentane-1,1′-naphthalen]-3′-yl)carbonyl)glycinate (115 mg, 257 μmol) was dissolved in TFA (2 mL) at ambient temperature. The reaction was stirred for 30 minutes and was then concentrated to give an oil, dissolved in ether, concentrated again to give an amorphous solid, precipitated with ether, filtered, washed with ether, and dried in a vacuum oven to give the title compound (21 mg) as a white solid. MS (m/z)=392 (M+H)+. Calculated for the C23H21NO5 391.14.

後処理

  1. concentrationwas then concentrated
  2. customto give an oil
  3. concentrationconcentrated again
  4. customto give an amorphous solid
  5. customprecipitated with ether
  6. filtrationfiltered
  7. washwashed with ether
  8. customdried in a vacuum oven

出典と根拠

ORDレコード
ord-8756e05bde4e4c198ecf2db6c31bc20d
出典データセット
uspto-grants-2011_04
特許番号
US07928139B2

反応ノート

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