Water → 4-Bromo-3,3,4,4-tetrafluorobutyl benzoate

HRID 2078520

反応式

HRID 2078520 の反応式
[Br:1][C:2]([F:10])([F:9])[C:3]([F:8])([F:7])[CH2:4][CH2:5]Br.[C:11]([O-:19])(=[O:18])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.[Na+].C1(C)C=CC=CC=1.O>CS(C)=O>[C:11]([O:19][CH2:5][CH2:4][C:3]([F:8])([F:7])[C:2]([Br:1])([F:10])[F:9])(=[O:18])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

参加物

6

反応物 4

HCID 962WaterHCID 1140TolueneHCID 877191,4-Dibromo-1,1,2,2-tetrafluorobutaneHCID 517055Sodium Benzoate

生成物 1

HCID 866548814-Bromo-3,3,4,4-tetrafluorobutyl benzoate

試薬・触媒・溶媒 1

HCID 679Dimethyl Sulfoxide溶媒

反応条件

温度
60 °C

実験手順

In 42 g of dimethyl sulfoxide were dissolved 10.0 g (0.035 mole) of 1,4-dibromo-1,1,2,2,-tetrafluorobutane and 5.0 g (0.035 mole) of sodium benzoate, which was stirred at 60° C. for 3.5 hours. The reaction solution was cooled to room temperature, after which toluene and water were added. The organic layer was taken out and washed once with 20 g of an aqueous saturated sodium hydrogen carbonate solution and twice with 20 g of an aqueous saturated sodium chloride solution. The organic layer was concentrated under reduced pressure, obtaining a compound, 4-bromo-3,3,4,4-tetrafluorobutyl benzoate. Colorless oily matter, 4.1 g.

後処理

  1. temperatureThe reaction solution was cooled to room temperature
  2. washwashed once with 20 g of an aqueous saturated sodium hydrogen carbonate solution and twice with 20 g of an aqueous saturated sodium chloride solution
  3. concentrationThe organic layer was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-4f99b308ff7845a3b6c8f924fb8f1d5f
出典データセット
uspto-grants-2011_04
特許番号
US07928262B2

関連ノート

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