Anthranilamide → N-(2-carbamoylphenyl)-2-chloro-6-methoxybenzamide

HRID 2079305

反応式

HRID 2079305 の反応式
[NH2:1][C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([NH2:6])=[O:5].[Cl:11][C:12]1[CH:20]=[CH:19][CH:18]=[C:17]([O:21][CH3:22])[C:13]=1[C:14](Cl)=[O:15]>N1C=CC=CC=1>[C:4]([C:3]1[CH:7]=[CH:8][CH:9]=[CH:10][C:2]=1[NH:1][C:14](=[O:15])[C:13]1[C:17]([O:21][CH3:22])=[CH:18][CH:19]=[CH:20][C:12]=1[Cl:11])(=[O:5])[NH2:6]

参加物

4

反応物 2

HCID 6942AnthranilamideHCID 12892677HCID 12892677、化合物

生成物 1

HCID 58010809N-(2-carbamoylphenyl)-2-chloro-6-methoxybenzamide収率 86%

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

反応条件

温度
0 °C

実験手順

2-Amino-benzamide (6.9 g, 50.8 mmol) was dissolved in 50 mL of pyridine and cooled to 0° C. 2-Chloro-6-methoxy-benzoyl chloride was added dropwise to the solution. After complete addition, the reaction was left to stir at room temperature for three days, which resulted in formation of a brown, cloudy solution. The reaction mixture was then poured into 150 mL of ice water. The precipitate was filtered and washed twice with water, twice with THF and finally twice with CH2Cl2 to obtain N-(2-carbamoylphenyl)-2-chloro-6-methoxybenzamide (13.3 g, 43.7 mmol, 86%).

後処理

  1. additionAfter complete addition
  2. waitthe reaction was left
  3. customwhich resulted in formation of a brown, cloudy solution
  4. filtrationThe precipitate was filtered
  5. washwashed twice with water, twice with THF and finally twice with CH2Cl2

出典と根拠

ORDレコード
ord-f96f3f7a4f8c4759956386e625934998
出典データセット
uspto-grants-2011_04
特許番号
US07928107B2

関連ノート

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