(E)-Methyl 3-(4-chloro-2-(trifluoromethyl)phenyl)acrylate → Methyl 3-(4-chloro-2-(trifluoromethyl)phenyl)propanoate

HRID 2079546ノート

反応式

HRID 2079546 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5](/[CH:8]=[CH:9]/[C:10]([O:12][CH3:13])=[O:11])=[C:4]([C:14]([F:17])([F:16])[F:15])[CH:3]=1.[H][H]>[Pd].C(OCC)(=O)C>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][C:10]([O:12][CH3:13])=[O:11])=[C:4]([C:14]([F:15])([F:16])[F:17])[CH:3]=1

参加物

5

反応物 2

HCID 57657554(E)-Methyl 3-(4-chloro-2-(trifluoromethyl)phenyl)acrylateHCID 178418361HCID 178418361、化合物

生成物 1

HCID 53419598Methyl 3-(4-chloro-2-(trifluoromethyl)phenyl)propanoate収率 99.2%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8857Ethyl Acetate溶媒

実験手順

A mixture of (E)-methyl 3-(4-chloro-2-(trifluoromethyl)phenyl)acrylate (5 g) and palladium on charcoal (10%, dry, 2 g) in ethyl acetate (50 ml) was stirred under balloon hydrogen pressure for 3 hours. After filtration, filtrate was concentrated to give methyl 3-(4-chloro-2-(trifluoromethyl)-phenyl)propanoate (5 g).

後処理

  1. filtrationAfter filtration, filtrate
  2. concentrationwas concentrated

出典と根拠

ORDレコード
ord-04587aef65dd4cf997fc751605d5d97a
出典データセット
uspto-grants-2011_04
特許番号
US07932251B2

反応ノート

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