Ethanol → HCID 10442276、化合物

HRID 2079658ノート

反応式

HRID 2079658 の反応式
[CH2:1](O)C.[CH3:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([C:12](=[O:14])[CH3:13])=[C:8]([N+:15]([O-])=O)[CH:7]=1>[Fe].C(O)(=O)C>[CH3:1][CH2:13][C:12]([C:9]1[CH:10]=[CH:11][C:6]([O:5][CH3:4])=[CH:7][C:8]=1[NH2:15])=[O:14]

参加物

5

反応物 2

HCID 702EthanolHCID 126437971-(4-Methoxy-2-nitrophenyl)ethan-1-one

生成物 1

HCID 10442276HCID 10442276、化合物収率 85%

試薬・触媒・溶媒 2

HCID 23925Iron触媒HCID 176Acetic Acid溶媒

実験手順

To a 1:1 mixture of ethanol and acetic acid was added 1-(4-methoxy-2-nitrophenyl)ethanone (1 eq) and Fe dust (3 eq) was added in portions. The reduction was complete in 1 h. The reaction mixture was filtered and then concentrated and partitioned between ethyl acetate and water. The organic layer was washed with saturated sodium bicarbonate and dried and concentrated to give methyl 1-(4-methoxy-2-aminophenyl)ethanone in 85% yield. ES/MS m/z 196 (MH+).

後処理

  1. additionwas added in portions
  2. filtrationThe reaction mixture was filtered
  3. concentrationconcentrated
  4. custompartitioned between ethyl acetate and water
  5. washThe organic layer was washed with saturated sodium bicarbonate
  6. customdried
  7. concentrationconcentrated

出典と根拠

ORDレコード
ord-6ee08297004a4054bb0a19e2647d02b2
出典データセット
uspto-grants-2011_04
特許番号
US07932262B2

反応ノート

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