Methyl iodide → 2,5-Dichloro-8-methoxyquinazoline
反応式
[Cl:1][C:2]1[N:11]=[CH:10][C:9]2[C:4](=[C:5]([OH:13])[CH:6]=[CH:7][C:8]=2[Cl:12])[N:3]=1.IC.[C:16](=O)([O-])[O-].[K+].[K+]>CN(C=O)C.C(OCC)(=O)C>[Cl:1][C:2]1[N:11]=[CH:10][C:9]2[C:4](=[C:5]([O:13][CH3:16])[CH:6]=[CH:7][C:8]=2[Cl:12])[N:3]=1参加物
6
実験手順
To a solution of 2,5-dichloroquinazolin-8-ol (1 eq) (See example 32 for synthesis) in DMF was added iodomethane (3 eq) and potassium carbonate (3 eq). The reaction mixture was stirred at room temperature for overnight. Diluted with ethyl acetate and washed with water and brine and dried over sodium sulfate. Filtered, evaporated and dried to provide product as a yellow solid in quantitative yield. ES/MS m/z 229.0 (MH+). Proceed for next step.
後処理
- washwashed with water and brine
- dry with materialdried over sodium sulfate
- filtrationFiltered
- customevaporated
- customdried
- customto provide product as a yellow solid in quantitative yield
出典と根拠
- ORDレコード
- ord-d8a9731cfcf247aabd6ccb73a1975476
- 出典データセット
- uspto-grants-2011_04
- 特許番号
- US07932262B2
反応ノート
読み込み中…