Hydrochloric Acid → 2-Amino-6-(2-cyanoethyl)-nicotinic Acid

HRID 2079951ノート

反応式

HRID 2079951 の反応式
[OH-].[Na+].C[O:4][C:5](=[O:17])[C:6]1[CH:11]=[CH:10][C:9]([CH2:12][CH2:13][C:14]#[N:15])=[N:8][C:7]=1[NH2:16].Cl>CO>[NH2:16][C:7]1[N:8]=[C:9]([CH2:12][CH2:13][C:14]#[N:15])[CH:10]=[CH:11][C:6]=1[C:5]([OH:17])=[O:4]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 583879902-Amino-6-(2-cyanoethyl)-nicotinic acid methyl ester

生成物 1

HCID 231303622-Amino-6-(2-cyanoethyl)-nicotinic Acid収率 81%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solvent mixture of 2N-sodium hydroxide aqueous solution (5 mL) and methanol (5 mL) was added 2-amino-6-(2-cyanoethyl)-nicotinic acid methyl ester (90 mg, 0.439 mmol), and the solution was stirred for 18 hours at room temperature. This mixed solution was neutralized with 5N-hydrochloric acid, then, extracted with ethyl acetate. This organic layer was dried over anhydrous magnesium sulfate, then, the solvent was evaporated in vacuo, and the title compound (68 mg, 0.355 mmol, 81%) was obtained as a yellowish brown solid.

後処理

  1. extractionextracted with ethyl acetate
  2. dry with materialThis organic layer was dried over anhydrous magnesium sulfate
  3. customthe solvent was evaporated in vacuo

出典と根拠

ORDレコード
ord-f7c01d8bc5624e4db515dffa190e9139
出典データセット
uspto-grants-2011_04
特許番号
US07932272B2

反応ノート

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