Hydrochloric Acid → HCID 23130694、化合物
反応式
C[O:2][C:3](=[O:14])[C:4]1[CH:9]=[CH:8][C:7]([CH2:10][CH2:11][F:12])=[N:6][C:5]=1[NH2:13].Cl>[OH-].[Na+].CO>[NH2:13][C:5]1[N:6]=[C:7]([CH2:10][CH2:11][F:12])[CH:8]=[CH:9][C:4]=1[C:3]([OH:14])=[O:2]参加物
5
実験手順
2-Amino-6-(2-fluoro-ethyl)-nicotinic acid methyl ester (77 mg, 0.387 mmol) was dissolved in an aqueous solution of 2N sodium hydroxide (5 mL) and methanol (5 mL), and the solution was stirred for 20 minutes at room temperature. This mixture solution was neutralized with 5N hydrochloric acid, then, extracted with ethyl acetate. The organic layer was separated, the solvent was evaporated in vacuo, and the title compound (64 mg, 0.348 mmol, 90%/65% purity) was obtained as a white solid.
後処理
- extractionextracted with ethyl acetate
- customThe organic layer was separated
- customthe solvent was evaporated in vacuo
出典と根拠
- ORDレコード
- ord-cdf97bfd60014ad0b4214e5255b52188
- 出典データセット
- uspto-grants-2011_04
- 特許番号
- US07932272B2
反応ノート
読み込み中…