Water → HCID 23130682、化合物

HRID 2080064ノート

反応式

HRID 2080064 の反応式
[H-].[Al+3].[Li+].[H-].[H-].[H-].[C:7]1([NH:13][CH2:14][C:15]2[CH:22]=[CH:21][C:18]([C:19]#[N:20])=[CH:17][CH:16]=2)[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.O>O1CCCC1>[NH2:20][CH2:19][C:18]1[CH:21]=[CH:22][C:15]([CH2:14][NH:13][C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[CH:16][CH:17]=1

参加物

5

反応物 3

HCID 962WaterHCID 11148468Benzonitrile, 4-[(phenylamino)methyl]-HCID 21226445Aluminium lithium hydride

生成物 1

HCID 23130682HCID 23130682、化合物収率 97.1%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

実験手順

Next, to a solution of lithium aluminum hydride (0.91 g, 24 mmol) in tetrahydrofuran (60 mL) was added a solution of the resulting 4-phenylaminomethyl-benzonitrile (2.0 g, 9.61 mmol) in tetrahydrofuran (5 mL), and the solution was stirred at room temperature for 2 hours. Water was added to the reaction solution, which was then extracted with ethyl acetate, dried over anhydrous magnesium sulfate, and the solvent was evaporated to obtain the title compound (1.98 g, 97%) as a yellow oil. This compound was used in the next reaction without purification.

後処理

  1. extractionwas then extracted with ethyl acetate
  2. dry with materialdried over anhydrous magnesium sulfate
  3. customthe solvent was evaporated

出典と根拠

ORDレコード
ord-e91aeb5823c2405ead7cad30ca605678
出典データセット
uspto-grants-2011_04
特許番号
US07932272B2

反応ノート

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