Hydrochloric Acid → 5-Benzylfuran-2-carbaldehyde

HRID 2080078

反応式

HRID 2080078 の反応式
[CH2:1]([C:8]1[O:12][C:11]([CH:13]2OCC[O:14]2)=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.CO.Cl.C(=O)(O)[O-].[Na+]>C(OCC)(=O)C.O1CCCC1>[CH2:1]([C:8]1[O:12][C:11]([CH:13]=[O:14])=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

7

反応物 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 516892Sodium BicarbonateHCID 231308032-(5-Benzyl-furan-2-yl)-[1,3]dioxolane

生成物 1

HCID 124185375-Benzylfuran-2-carbaldehyde収率 78.8%

試薬・触媒・溶媒 2

HCID 8028Tetrahydrofuran溶媒HCID 8857Ethyl Acetate溶媒

実験手順

The resulting 2-(5-benzyl-furan-2-yl)-[1,3]dioxolane (3.8 g, 16.5 mmol) was suspended in a mixture solution of methanol (15 mL), tetrahydrofuran (10 mL) and 2N hydrochloric acid (15 mL), and the solution was stirred at room temperature for 2 hours. Ethyl acetate and an aqueous solution of sodium bicarbonate were added to the reaction solution, which was then partitioned, the organic layer was washed with water twice and dried over anhydrous sodium sulfate. The solvent was evaporated, and the title compound (2.5 g, 13 mmol) was obtained as a brown oil.

後処理

  1. customwas then partitioned
  2. washthe organic layer was washed with water twice
  3. dry with materialdried over anhydrous sodium sulfate
  4. customThe solvent was evaporated

出典と根拠

ORDレコード
ord-8b5a57d2504e4029977fd7f27426edd2
出典データセット
uspto-grants-2011_04
特許番号
US07932272B2

関連ノート

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