Water → 2-(5-Oxiranyl-furan-2-yl)-[1,3]dioxolane

HRID 2080111

反応式

HRID 2080111 の反応式
[O:1]1[CH2:5][CH2:4][O:3][CH:2]1[C:6]1[O:10][C:9]([CH:11]=[O:12])=[CH:8][CH:7]=1.[Br-].[CH3:14][S+](C)C.[OH-].[K+].O>C(#N)C>[O:12]1[CH2:14][CH:11]1[C:9]1[O:10][C:6]([CH:2]2[O:3][CH2:4][CH2:5][O:1]2)=[CH:7][CH:8]=1

参加物

6

反応物 4

HCID 962WaterHCID 14797Potassium HydroxideHCID 2735154Sulfonium, trimethyl-, bromide (1:1)HCID 146165975-(1,3-Dioxolan-2-yl)furan-2-carbaldehyde

生成物 1

HCID 231307652-(5-Oxiranyl-furan-2-yl)-[1,3]dioxolane収率 102.1%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

5-[1,3]Dioxolan-2-yl-furan-2-carbaldehyde (2.03 g, 12.1 mmol), trimethylsulfonium bromide (1.90 g, 12.1 mmol) and potassium hydroxide (779 mg, 13.9 mmol) were suspended in acetonitrile (75 mL), and the solution was stirred overnight at room temperature. Water was added to the reaction solution, which was then extracted with ethyl acetate, the organic layer was washed with brine and dried over anhydrous magnesium sulfate. The solvent was evaporated in vacuo, 2-(5-oxiranyl-furan-2-yl)-[1,3]dioxolane (2.25 g) was obtained as a pale yellow oil.

後処理

  1. extractionwas then extracted with ethyl acetate
  2. washthe organic layer was washed with brine
  3. dry with materialdried over anhydrous magnesium sulfate
  4. customThe solvent was evaporated in vacuo

出典と根拠

ORDレコード
ord-f386fb9bc7834aaca3b002b00c2987de
出典データセット
uspto-grants-2011_04
特許番号
US07932272B2

関連ノート

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