Hydrochloric Acid → Ethyl 5-Hydroxy-4-isoxazolecarboxylate
反応式
[CH2:1]([O:3][C:4](=[O:15])[C:5](=[CH:11]OCC)[C:6]([O:8]CC)=[O:7])[CH3:2].Cl.NO.C([N:21](CC)CC)C.Cl>C(O)C.O>[CH2:1]([O:3][C:4]([C:5]1[C:6](=[O:7])[O:8][NH:21][CH:11]=1)=[O:15])[CH3:2]参加物
7
実験手順
2-Ethoxymethylene-malonic acid diethyl ester (5.00 g, 23.1 mmol), hydroxylamine hydrochloride (4.01 g, 57.8 mmol) and triethylamine (8.06 mL, 57.8 mmol) were dissolved in ethanol (100 mL), the solution was stirred at room temperature for 17 hours, then, the solution was stirred for 4.5 hours under reflux. The reaction solution was cooled to room temperature, water was added, and 1N hydrochloric acid was added until a salt precipitated. The precipitated salt was collected by filtration, and a hydrochloride salt of the title compound (2.39 g, 15.2 mmol, 66%) was obtained as a white solid.
後処理
- stirringthe solution was stirred for 4.5 hours
- temperatureunder reflux
- temperatureThe reaction solution was cooled to room temperature
- customprecipitated
- filtrationThe precipitated salt was collected by filtration
出典と根拠
- ORDレコード
- ord-8f6b96a04688418ea6287645e743fecb
- 出典データセット
- uspto-grants-2011_04
- 特許番号
- US07932272B2
反応ノート
読み込み中…