5-Benzylfuran-2-carbaldehyde → 5-(Phenylmethyl)-2-furanmethanamine
反応式
[CH2:1]([C:8]1[O:12][C:11]([CH:13]=O)=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH3:15].CO>[Ni]>[CH2:1]([C:8]1[O:12][C:11]([CH2:13][NH2:15])=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1参加物
4
実験手順
7N Ammonia/methanol(40 mL) and Raney nickel(3 g) were added to 5-benzyl-furan-2-carbaldehyde described in Preparation Example 39 (2.5 g, 13 mmol), and the solution was stirred for 22 hours under hydrogen atmosphere at room temperature. After removing the catalyst by filtering through Celite pad, the solvent was evaporated in vacuo and C-(5-benzyl-furan-2-yl)methylamine (1.6 g, 8.6 mmol, 65.8%) was obtained.
後処理
- customAfter removing the catalyst
- filtrationby filtering through Celite pad
- customthe solvent was evaporated in vacuo
出典と根拠
- ORDレコード
- ord-fa9049e0f9524da9bf4ee48ab4ee6885
- 出典データセット
- uspto-grants-2011_04
- 特許番号
- US07932272B2
反応ノート
読み込み中…