5-Benzylfuran-2-carbaldehyde → 5-(Phenylmethyl)-2-furanmethanamine

HRID 2080254

反応式

HRID 2080254 の反応式
[CH2:1]([C:8]1[O:12][C:11]([CH:13]=O)=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH3:15].CO>[Ni]>[CH2:1]([C:8]1[O:12][C:11]([CH2:13][NH2:15])=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 124185375-Benzylfuran-2-carbaldehydeHCID 21705897Ammonia methanol

生成物 1

HCID 231306205-(Phenylmethyl)-2-furanmethanamine収率 65.8%

試薬・触媒・溶媒 1

HCID 935Nickel触媒

実験手順

7N Ammonia/methanol(40 mL) and Raney nickel(3 g) were added to 5-benzyl-furan-2-carbaldehyde described in Preparation Example 39 (2.5 g, 13 mmol), and the solution was stirred for 22 hours under hydrogen atmosphere at room temperature. After removing the catalyst by filtering through Celite pad, the solvent was evaporated in vacuo and C-(5-benzyl-furan-2-yl)methylamine (1.6 g, 8.6 mmol, 65.8%) was obtained.

後処理

  1. customAfter removing the catalyst
  2. filtrationby filtering through Celite pad
  3. customthe solvent was evaporated in vacuo

出典と根拠

ORDレコード
ord-fa9049e0f9524da9bf4ee48ab4ee6885
出典データセット
uspto-grants-2011_04
特許番号
US07932272B2

関連ノート

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