Isobutyraldehyde → HCID 86646581、化合物

HRID 2080553ノート

反応式

HRID 2080553 の反応式
[Cl:1][C:2]1[N:7]=[CH:6][C:5]([CH2:8][NH:9][CH2:10][CH2:11][S:12][CH2:13][C:14]2[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][CH:15]=2)=[CH:4][CH:3]=1.[CH:22](=O)[CH:23]([CH3:25])[CH3:24].C(O[BH-](OC(=O)C)OC(=O)C)(=O)C.[Na+].S([O-])([O-])(=O)=O.[Mg+2]>ClCCCl>[Cl:1][C:2]1[N:7]=[CH:6][C:5]([CH2:8][N:9]([CH2:10][CH2:11][S:12][CH2:13][C:14]2[CH:15]=[CH:16][C:17]([O:20][CH3:21])=[CH:18][CH:19]=2)[CH2:22][CH:23]([CH3:25])[CH3:24])=[CH:4][CH:3]=1

参加物

6

反応物 4

HCID 6561IsobutyraldehydeHCID 24083Sulfuric acid magnesium salt (1:1)HCID 5049666Sodium triacetoxyborohydrideHCID 86646582HCID 86646582、化合物

生成物 1

HCID 86646581HCID 86646581、化合物

試薬・触媒・溶媒 1

HCID 111,2-Dichloroethane溶媒

実験手順

This compound was made in a manner analogous to that set forth in Step A of Example 3, using 2.0 grams (0.0062 mole) of [(6-chloro(3-pyridyl))methyl]{2-[(4-methoxyphenyl)methylthio]ethyl}-amine, 0.45 gram (0.0062 mole) of isobutyraldehyde, 2.0 gram (0.0093 mole) of sodium triacetoxyborohydride and 1.5 grams (0.0124 mole) of magnesium sulfate in 40 mL of 1,2-dichloroethane. The yield of the subject compound after one column chromatography purification on silica gel, eluting with a mixture of ethyl acetate and hexanes, was 2.05 grams. The NMR spectrum was consistent with the proposed structure.

後処理

  1. customThe yield of the subject compound after one column chromatography purification on silica gel
  2. washeluting with a mixture of ethyl acetate and hexanes

出典と根拠

ORDレコード
ord-123cf99f777941cfa21c16cf510baad6
出典データセット
uspto-grants-2011_04
特許番号
US07932393B2

反応ノート

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