Sodium Hydroxide → 4-[(Dipropylamino)methyl]benzoic acid

HRID 2080793

反応式

HRID 2080793 の反応式
C[O:2][C:3](=[O:18])[C:4]1[CH:9]=[CH:8][C:7]([CH2:10][N:11]([CH2:15][CH2:16][CH3:17])[CH2:12][CH2:13][CH3:14])=[CH:6][CH:5]=1.[OH-].[Na+]>CO>[CH2:12]([N:11]([CH2:10][C:7]1[CH:8]=[CH:9][C:4]([C:3]([OH:18])=[O:2])=[CH:5][CH:6]=1)[CH2:15][CH2:16][CH3:17])[CH2:13][CH3:14]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 23079192Methyl 4-dipropylaminomethylbenzoate

生成物 1

HCID 167713874-[(Dipropylamino)methyl]benzoic acid収率 98.4%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

The compound (883 mg) obtained in Example 29-2 was dissolved in methanol (18 ml) and added with a 1 mol/l sodium hydroxide aqueous solution (9.0 ml) and the whole was stirred overnight at room temperature. After completion of the reaction, the solvent was distilled off under reduced pressure. The residue was dissolved in 1 mol/l hydrochloric acid, subjected to extraction with chloroform, and dried with anhydrous sodium sulfate. After filtration, the solvent was distilled off and the residue was dried under vacuum, thereby obtaining the subject compound (820 mg) as a white solid.

後処理

  1. customAfter completion of the reaction
  2. distillationthe solvent was distilled off under reduced pressure
  3. dissolutionThe residue was dissolved in 1 mol/l hydrochloric acid
  4. extractionsubjected to extraction with chloroform
  5. dry with materialdried with anhydrous sodium sulfate
  6. filtrationAfter filtration
  7. distillationthe solvent was distilled off
  8. customthe residue was dried under vacuum

出典と根拠

ORDレコード
ord-4beb7815a0ad4c46a35bd951ea0a5971
出典データセット
uspto-grants-2011_04
特許番号
US07932281B2

関連ノート

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