(3-Chloro-4-[[(4-dipropylamino-butyl)-methyl-amino]-methyl]-phenyl)-methanol → HCID 23155409、化合物

HRID 2080867ノート

反応式

HRID 2080867 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH2:22][OH:23])[CH:5]=[CH:6][C:7]=1[CH2:8][N:9]([CH2:11][CH2:12][CH2:13][CH2:14][N:15]([CH2:19][CH2:20][CH3:21])[CH2:16][CH2:17][CH3:18])[CH3:10]>C(Cl)(Cl)Cl.[O-2].[O-2].[Mn+4]>[Cl:1][C:2]1[CH:3]=[C:4]([CH:5]=[CH:6][C:7]=1[CH2:8][N:9]([CH2:11][CH2:12][CH2:13][CH2:14][N:15]([CH2:19][CH2:20][CH3:21])[CH2:16][CH2:17][CH3:18])[CH3:10])[CH:22]=[O:23]

参加物

4

反応物 1

HCID 23155369(3-Chloro-4-[[(4-dipropylamino-butyl)-methyl-amino]-methyl]-phenyl)-methanol

生成物 1

HCID 23155409HCID 23155409、化合物収率 88.7%

試薬・触媒・溶媒 2

HCID 178418406HCID 178418406、化合物触媒HCID 6212Chloroform溶媒

実験手順

The compound (290.8 mg) obtained in Example 77-4 was dissolved in chloroform (6 ml). The reaction solution was added with manganese dioxide (1.4331 g) and the whole was stirred at room temperature for 22 hours. The catalyst was filtrated out through Celite. The filtrate was concentrated under reduced pressure, thereby obtaining the subject compound (256.4 mg) as a colorless oily substance.

後処理

  1. filtrationThe catalyst was filtrated out through Celite
  2. concentrationThe filtrate was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-c6437f74b1f1402fa4c82388ba496e7d
出典データセット
uspto-grants-2011_04
特許番号
US07932281B2

反応ノート

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