N-[1-(3-nitrobenzyl)indol-5-ylcarbonyl]-2-methylbenzene sulphonamide → HCID 19780416、化合物

HRID 2081700

反応式

HRID 2081700 の反応式
[N+:1]([C:4]1[CH:5]=[C:6]([CH:30]=[CH:31][CH:32]=1)[CH2:7][N:8]1[C:16]2[C:11](=[CH:12][C:13]([C:17]([NH:19][S:20]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=3[CH3:29])(=[O:22])=[O:21])=[O:18])=[CH:14][CH:15]=2)[CH:10]=[CH:9]1)([O-])=O.[H][H]>CO.C(OCC)(=O)C.[Pd]>[NH2:1][C:4]1[CH:5]=[C:6]([CH:30]=[CH:31][CH:32]=1)[CH2:7][N:8]1[C:16]2[C:11](=[CH:12][C:13]([C:17]([NH:19][S:20]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=3[CH3:29])(=[O:22])=[O:21])=[O:18])=[CH:14][CH:15]=2)[CH:10]=[CH:9]1

参加物

6

反応物 2

HCID 19780401N-[1-(3-nitrobenzyl)indol-5-ylcarbonyl]-2-methylbenzene sulphonamideHCID 178418361HCID 178418361、化合物

生成物 1

HCID 19780416HCID 19780416、化合物

試薬・触媒・溶媒 3

HCID 23938Palladium触媒HCID 887Methanol溶媒HCID 8857Ethyl Acetate溶媒

実験手順

The nitrobenzylindole (Example 3) (2.7 g) was dissolved in methanol (125 ml) and ethyl acetate (125 ml), and 10% palladium on charcoal (0.5 g) added. The reaction mixture was hydrogenated in a Parr bottle at 50 p.s.i. with shaking until hydrogen uptake was complete (approximately 1 hour). The catalyst was filtered off through Celite and the solvent removed in vacuo to give N-[1-(3-aminobenzyl)indol-5-ylcarbonyl]-2-methylbenzene sulphonamide as a foam. This crude product was used in the next step without purification.

後処理

  1. custom(approximately 1 hour)
  2. filtrationThe catalyst was filtered off through Celite
  3. customthe solvent removed in vacuo

出典と根拠

ORDレコード
ord-845656225af949548418a55035863d1e
出典データセット
uspto-grants-1993_02
特許番号
US05185361

関連ノート

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