Sodium Hydroxide → 2-(4,6-Dimethoxypyrimidin-2-yl)acetic acid

HRID 2081913ノート

反応式

HRID 2081913 の反応式
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[N:6]=[C:5]([CH2:11][C:12]([O:14]C)=[O:13])[N:4]=1.[OH-].[Na+]>O>[CH3:10][O:9][C:7]1[CH:8]=[C:3]([O:2][CH3:1])[N:4]=[C:5]([CH2:11][C:12]([OH:14])=[O:13])[N:6]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 10921798Methyl 2-(4,6-dimethoxypyrimidin-2-yl)acetate

生成物 1

HCID 124207552-(4,6-Dimethoxypyrimidin-2-yl)acetic acid

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

20 g of methyl (4,6-dimethoxypyrimidin-2-yl)acetate are stirred for 2 hours at 50° C. with 3.9 g of sodium hydroxide in 300 ml of water. The mixture is cooled to room temperature and extracted three times using diethyl ether, and the aqueous phase is acidified to pH 2 using 2N hydrochloric acid and extracted four times using 150 ml portions of ethyl acetate. The organic phase is dried over sodium sulfate, the solvent is distilled off, and the residue is dried in vacuo. This gives 13.1 g of (4,6-dimethoxypyrimidin-2-yl)acetic acid of melting point 175°-177° C.

後処理

  1. extractionextracted three times
  2. extractionextracted four times
  3. dry with materialThe organic phase is dried over sodium sulfate
  4. distillationthe solvent is distilled off
  5. customthe residue is dried in vacuo

出典と根拠

ORDレコード
ord-ade8fcd6e51e4e7aa1029e4ad7afe145
出典データセット
uspto-grants-1993_02
特許番号
US05186736

反応ノート

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