Diethyl Ether → 142348-17-2

HRID 2082130ノート

反応式

HRID 2082130 の反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[N:7]1[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]1.[Br:13][CH2:14][CH2:15][CH2:16][CH2:17]Br.C(=O)([O-])[O-].[Na+].[Na+].CCOCC>C(O)(C)C>[Br-:13].[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[N:7]1[CH2:8][CH2:9][N+:10]2([CH2:17][CH2:16][CH2:15][CH2:14]2)[CH2:11][CH2:12]1

参加物

6

反応物 4

HCID 3283Diethyl EtherHCID 80561,4-DibromobutaneHCID 10340Sodium CarbonateHCID 944591-(2-Pyridyl)piperazine

生成物 1

HCID 658423142348-17-2

試薬・触媒・溶媒 1

HCID 3776Isopropanol溶媒

実験手順

A mixture of 40.8 g (0.25 mol) of 1-(2-pyridyl) piperazine (IV), 75.5 ml (134.9 g, 0.625 mol) of 1,4-dibromobutane (V) and 27.5 g (0.26 mol) of sodium carbonate was refluxed in 500 g of isopropyl alcohol for 16 hours, the hot mixture was filtered off from the salt precipitate, cooled, and the crystalline product was isolated. The additional amount of the product can be obtained by dilution of the mother liquor with a double volume of ether.

後処理

  1. filtrationthe hot mixture was filtered off from the salt precipitate
  2. temperaturecooled
  3. customthe crystalline product was isolated

出典と根拠

ORDレコード
ord-40188b3f3f644e2abd31b062beccdd31
出典データセット
uspto-grants-1993_02
特許番号
US05187277

反応ノート

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