Pyridine → HCID 67882217、化合物
反応式
[Cl:1][CH2:2][CH2:3][NH:4][C:5]([O:7][CH2:8][C@@H:9]([CH2:12][O:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH3:31])[O:10][CH3:11])=[O:6].[N:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1>>[Cl-:1].[CH3:11][O:10][C@H:9]([CH2:12][O:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH3:31])[CH2:8][O:7][C:5]([NH:4][CH2:3][CH2:2][N+:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1)=[O:6]参加物
3
反応条件
- 温度
- 80 °C
実験手順
A solution of 0.035 g of (R)-1-O-[(2-chloroethyl)carbamyl]-2-O-methyl-3-O-octadecylglycerine is treated with 5 ml of pyridine and heated at 80° C. for 3 days. The solution is evaporated and the residue is treated with toluene by azeotropic distillation. The residue is recrystallized from acetone. There is obtained 1-[2-[1-[(R)-2-methoxy-3-(octadecyloxy)propoxy]formamido]ethyl]pyridinium chloride of melting point 65° C. (dec.).
後処理
- customThe solution is evaporated
- additionthe residue is treated with toluene by azeotropic distillation
- customThe residue is recrystallized from acetone