N-(1-benzylpiperid-4-yl)-N-methylpropionamide → N-Methyl-N-(piperidin-4-yl)propionamide

HRID 2082345ノート

反応式

HRID 2082345 の反応式
C([N:8]1[CH2:13][CH2:12][CH:11]([N:14]([CH3:19])[C:15](=[O:18])[CH2:16][CH3:17])[CH2:10][CH2:9]1)C1C=CC=CC=1>C(O)C.[OH-].[Pd+2].[OH-]>[NH:8]1[CH2:13][CH2:12][CH:11]([N:14]([CH3:19])[C:15](=[O:18])[CH2:16][CH3:17])[CH2:10][CH2:9]1

参加物

4

反応物 1

HCID 19761195N-(1-benzylpiperid-4-yl)-N-methylpropionamide

生成物 1

HCID 19761222N-Methyl-N-(piperidin-4-yl)propionamide収率 60%

試薬・触媒・溶媒 2

HCID 9942167Palladium hydroxide触媒HCID 702Ethanol溶媒

実験手順

31 g of the amine obtained in Stage B are hydrogenated in 350 ml of ethanol with 1 g of palladium hydroxide at atmospheric pressure and room temperature. The mixture is filtered and evaporated to yield the desired product in the form of an oil.

後処理

  1. filtrationThe mixture is filtered
  2. customevaporated

出典と根拠

ORDレコード
ord-0295d3c8d845438e84752f73a7d8dbc2
出典データセット
uspto-grants-1993_02
特許番号
US05189045

反応ノート

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