Benzyl Chloride → HCID 2845263、化合物

HRID 2082356ノート

反応式

HRID 2082356 の反応式
[C:1]([N:4]1[CH2:9][CH2:8][CH:7]([NH:10][CH3:11])[CH2:6][CH2:5]1)(=[O:3])[CH3:2].[CH2:12](Cl)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.C(=O)([O-])[O-].[Na+].[Na+]>C(O)C>[C:1]([N:4]1[CH2:9][CH2:8][CH:7]([NH:10][CH2:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH2:6][CH2:5]1)(=[O:3])[CH3:2]

参加物

5

反応物 3

HCID 7503Benzyl ChlorideHCID 10340Sodium CarbonateHCID 197612651-[4-(Methylamino)piperidin-1-yl]ethan-1-one

生成物 1

HCID 2845263HCID 2845263、化合物収率 65%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture containing 0.5 mol of the compound obtained in Stage A of Example 19, 0.5 M benzyl chloride and 1 M sodium carbonate in 650 ml of ethanol is refluxed for one night. The precipitate formed is filtered off, the solvent is evaporated, the evaporation residue is taken up in 1N hydrochloric acid and extracted with diethyl ether, and the ethereal extract is rendered basic with sodium hydroxide solution and extracted with ethyl acetate to obtain the desired compound.

後処理

  1. temperatureis refluxed for one night
  2. customThe precipitate formed
  3. filtrationis filtered off
  4. customthe solvent is evaporated
  5. extractionextracted with diethyl ether
  6. extractionthe ethereal extract
  7. extractionextracted with ethyl acetate

出典と根拠

ORDレコード
ord-dc67c0fc84074265b368bcbdce43d6ea
出典データセット
uspto-grants-1993_02
特許番号
US05189045

反応ノート

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