Water → Methyl 4-(hydroxymethyl)cinnamate

HRID 2082571ノート

反応式

HRID 2082571 の反応式
[CH:1]([C:3]1[CH:14]=[CH:13][C:6]([CH:7]=[CH:8][C:9]([O:11][CH3:12])=[O:10])=[CH:5][CH:4]=1)=[O:2].[BH4-].[Na+].O>CO>[OH:2][CH2:1][C:3]1[CH:4]=[CH:5][C:6]([CH:7]=[CH:8][C:9]([O:11][CH3:12])=[O:10])=[CH:13][CH:14]=1

参加物

5

反応物 3

HCID 962WaterHCID 4311764Sodium borohydrideHCID 53401287Methyl 3-(4-formylphenyl)-2-propenoate

生成物 1

HCID 54313853Methyl 4-(hydroxymethyl)cinnamate収率 93.5%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of methyl 4-formylcinnamate (5.58 g) in methanol (100 ml) was added sodium borohydride (0.4 g), and the mixture was stirred at room temperature for an hour. The reaction mixture was poured into water and extracted with methylene chloride. The methylene chloride layer was washed with a saturated aqueous sodium chloride solution and dried over anhydrous magnesium sulfate. Evaporation of the solvent under reduced pressure gave methyl 4-(hydroxymethyl)cinnamate (5.27 g).

後処理

  1. extractionextracted with methylene chloride
  2. washThe methylene chloride layer was washed with a saturated aqueous sodium chloride solution
  3. dry with materialdried over anhydrous magnesium sulfate
  4. customEvaporation of the solvent under reduced pressure

出典と根拠

ORDレコード
ord-47e771eab5a54f59994575d78fcbd563
出典データセット
uspto-grants-1993_02
特許番号
US05189211

反応ノート

読み込み中…