3,3-Dimethyl-2,5-hexanedione → 5-Hydroxy-3,3-dimethylhexan-2-one

HRID 2082792ノート

反応式

HRID 2082792 の反応式
[CH3:1][C:2]([CH3:10])([CH2:6][C:7](=[O:9])[CH3:8])[C:3](=[O:5])[CH3:4].C1C2B3C(CCC2)CCCC3CC1.[Li]>O1CCCC1>[CH3:1][C:2]([CH3:10])([CH2:6][CH:7]([OH:9])[CH3:8])[C:3](=[O:5])[CH3:4]

参加物

4

反応物 2

HCID 1647423,3-Dimethyl-2,5-hexanedioneHCID 70418318Lithium perhydro-9b-boraphenalylhydride

生成物 1

HCID 203606715-Hydroxy-3,3-dimethylhexan-2-one収率 90%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

反応条件

温度
0 °C

実験手順

In a flask is placed 100 mmoles of 3,3-dimethyl-2,5-hexanedione in 50 ml. of tetrahydrofuran. The reaction mixture is cooled to 0° C. and 100 mmoles of lithium perhydro-9b-boraphenalylhydride is added slowly. A 90% yield of 3,3-dimethyl-5-hydroxy-2-hexanone is obtained.

後処理

  1. customIn a flask is placed

出典と根拠

ORDレコード
ord-bb0063a3d7fa446099adeed3cdc06e61
出典データセット
uspto-grants-1978_04
特許番号
US04082810

反応ノート

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