Hydrazine hydrate (1:1) → 6-(4-chloro-3-hydroxyphenyl)-4,5-dihydro-3(2H)-pyridazinone

反応式

[Cl:1][C:2]1[CH:14]=[CH:13][C:5]([C:6]([CH2:8][CH2:9][C:10](O)=[O:11])=O)=[CH:4][C:3]=1[OH:15].O.[NH2:17][NH2:18]>>[Cl:1][C:2]1[CH:14]=[CH:13][C:5]([C:6]2[CH2:8][CH2:9][C:10](=[O:11])[NH:17][N:18]=2)=[CH:4][C:3]=1[OH:15]

参加物

反応物 2

HCID 24654Hydrazine hydrate (1:1)

HCID 203607373-(4-Chloro-3-hydroxybenzoyl)propionic acid

生成物 1

HCID 203608016-(4-chloro-3-hydroxyphenyl)-4,5-dihydro-3(2H)-pyridazinone

実験手順

3-(4-chloro-3-hydroxybenzoyl)propionic acid was cyclised with hydrazine hydrate in a similar manner to that described in Example 3 (i) to give 6-(4-chloro-3-hydroxyphenyl)-4,5-dihydro-3(2H)-pyridazinone.

出典と根拠

ORDレコード: ord-0df25419c8b544e0b48269a19d1b66b0
出典データセット: uspto-grants-1978_04
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04082843

反応ノート

読み込み中…