Acetic Acid → 2-Benzyl-5-(bromomethyl)-3-(methylsulfanyl)benzene-1-sulfonamide

HRID 2082875ノート

反応式

HRID 2082875 の反応式
[CH2:1]([C:8]1[C:15]([S:16](=[O:19])(=[O:18])[NH2:17])=[CH:14][C:11]([CH2:12]O)=[CH:10][C:9]=1[S:20][CH3:21])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(O)(=O)C.[BrH:26]>O>[CH2:1]([C:8]1[C:15]([S:16](=[O:19])(=[O:18])[NH2:17])=[CH:14][C:11]([CH2:12][Br:26])=[CH:10][C:9]=1[S:20][CH3:21])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

5

反応物 3

HCID 176Acetic AcidHCID 260Hydrogen BromideHCID 20360840HCID 20360840、化合物

生成物 1

HCID 202945462-Benzyl-5-(bromomethyl)-3-(methylsulfanyl)benzene-1-sulfonamide

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

4-Benzyl-3-methylthio-5-sulfamylbenzyl alcohol (10 g; prepared as described in Example 1) is while stirring added in portions to acetic acid saturated with dry hydrogen bromide (50 ml), and the mixture is stirred for 24 hours. The resulting solution is diluted with water (100 ml) and cooled to precipitate crude 4-benzyl-3-methylthio-5-sulfamylbenzyl bromide. After recrystallization from methanol it is obtained with a melting point of 149°-150° C.

後処理

  1. stirringthe mixture is stirred for 24 hours
  2. temperaturecooled
  3. customto precipitate crude 4-benzyl-3-methylthio-5-sulfamylbenzyl bromide
  4. customAfter recrystallization from methanol it
  5. customis obtained with a melting point of 149°-150° C.

出典と根拠

ORDレコード
ord-ef3cca4b265c4bd985f8e350a76d95c7
出典データセット
uspto-grants-1978_04
特許番号
US04082851

反応ノート

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