Acetic Acid → 3-Amino-4-benzyl-5-sulfamylbenzylbromide hydrobromide

HRID 2082876ノート

反応式

HRID 2082876 の反応式
[NH2:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([S:17](=[O:20])(=[O:19])[NH2:18])[C:9]=1[CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[CH2:5]O.C(O)(=O)C.[BrH:25]>C(OCC)C>[BrH:25].[NH2:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([S:17](=[O:20])(=[O:19])[NH2:18])[C:9]=1[CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[CH2:5][Br:25]

参加物

5

反応物 3

HCID 176Acetic AcidHCID 260Hydrogen BromideHCID 536869293-Amino-2-benzyl-5-(hydroxymethyl)benzene-1-sulfonamide

生成物 1

HCID 202945373-Amino-4-benzyl-5-sulfamylbenzylbromide hydrobromide

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

3-Amino-4-benzyl-5-sulfamylbenzyl alcohol (12.5 g; prepared as described in Example 4) is while stirring added in portions to acetic acid saturated with dry hydrogen bromide (60 ml), and the mixture is stirred for 24 hours. The resulting solution is diluted with diethyl ether (150 ml) and cooled to precipitate 3-amino-4-benzyl-5-sulfamylbenzyl bromide hydrobromide as a hygroscopic material with a melting point of 195°-198° C.

後処理

  1. stirringthe mixture is stirred for 24 hours
  2. temperaturecooled
  3. customto precipitate 3-amino-4-benzyl-5-sulfamylbenzyl bromide hydrobromide as a hygroscopic material with a melting point of 195°-198° C.

出典と根拠

ORDレコード
ord-1d863e0d0f6b49e69c8cf574965082b2
出典データセット
uspto-grants-1978_04
特許番号
US04082851

反応ノート

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