ホームMCPワークベンチSkills
ホームワークベンチ通知マイページ
llms.txt · MCPガイドプライバシーポリシー · 利用規約 · サポートv1.8.0
  1. ホーム
  2. /反応

Acetonitrile → HCID 20358774、化合物

HRID 2082930
ノート
印刷プレビュー

反応式

HRID 2082930 の反応式
[OH:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([NH2:12])=[CH:4][C:3]=1[C:13]([NH:15][CH2:16][CH2:17][CH2:18][O:19][C:20]1[CH:25]=[CH:24][C:23]([C:26]([CH2:29][CH3:30])([CH3:28])[CH3:27])=[CH:22][C:21]=1[C:31]([CH2:34][CH3:35])([CH3:33])[CH3:32])=[O:14].[Cl:36][C:37]([Cl:42])([Cl:41])[C:38](Cl)=[O:39].C(N(CC)CC)C.C(#N)C>O>[OH:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([NH:12][C:38](=[O:39])[C:37]([Cl:42])([Cl:41])[Cl:36])=[CH:4][C:3]=1[C:13]([NH:15][CH2:16][CH2:17][CH2:18][O:19][C:20]1[CH:25]=[CH:24][C:23]([C:26]([CH2:29][CH3:30])([CH3:27])[CH3:28])=[CH:22][C:21]=1[C:31]([CH2:34][CH3:35])([CH3:33])[CH3:32])=[O:14]
参加物実験手順後処理出典と根拠反応ノート

参加物

6

反応物 4

HCID 6342AcetonitrileHCID 6420Trichloroacetyl chlorideHCID 8471TriethylamineHCID 12525034HCID 12525034、化合物

生成物 1

HCID 20358774HCID 20358774、化合物

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

14.3 g of 1-hydroxy-4-amino-N-[γ-(2,4-di-tert-amylphenoxy)propyl]-2-naphthamide obtained in Step (b) of Synthesis I, 6 g of trichloroacetyl chloride and 3.3 g of triethylamine were added to 300 ml of acetonitrile, and the mixture was refluxed for 4 hours. After conclusion of the reaction, the reaction solution was condensed to 100 ml and water was added thereto. The solution was then extracted with ethyl acetate. After removal of the ethyl acetate by distillation, n-hexane was added to the residue. The solid precipitate was separated by filtration and recrystallized from ethanol to obtain the object compound. Yield: 10 g. Melting point: 190° - 192° C.

後処理

  1. temperaturethe mixture was refluxed for 4 hours
  2. customAfter conclusion of the reaction
  3. additionwas added
  4. extractionThe solution was then extracted with ethyl acetate
  5. customAfter removal of the ethyl acetate
  6. distillationby distillation, n-hexane
  7. additionwas added to the residue
  8. customThe solid precipitate was separated by filtration
  9. customrecrystallized from ethanol
  10. customto obtain the object compound

出典と根拠

ORDレコード
ord-cd8db21af4244c56ba69da2b769a7398
出典データセット
uspto-grants-1978_04
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US04083721

反応ノート

読み込み中…

このページの内容参加物実験手順後処理出典と根拠反応ノート