N-(4-chlorobenzenesulphonyl)-N',S-dimethylisothiourea → HCID 178485013、化合物

HRID 2083033ノート

反応式

HRID 2083033 の反応式
[CH3:1][C:2]1[N:3]=[CH:4][NH:5][C:6]=1[CH2:7][S:8][CH2:9][CH2:10][NH2:11].[Cl:12][C:13]1[CH:18]=[CH:17][C:16]([S:19]([NH:22][C:23](=[N:26][CH3:27])SC)(=[O:21])=[O:20])=[CH:15][CH:14]=1>C(#N)C>[Cl:12][C:13]1[CH:14]=[CH:15][C:16]([S:19]([NH:22][C:23]([NH:26][CH3:27])=[N:11][CH2:10][CH2:9][S:8][CH2:7][C:6]2[NH:5][CH:4]=[N:3][C:2]=2[CH3:1])(=[O:20])=[O:21])=[CH:17][CH:18]=1

参加物

4

反応物 2

HCID 22756462N-(4-chlorobenzenesulphonyl)-N',S-dimethylisothioureaHCID 178433288HCID 178433288、化合物

生成物 1

HCID 178485013HCID 178485013、化合物収率 59.1%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

A solution of 4-methyl-5-((2-aminoethyl)thiomethyl)imidazole (3.33 g.) and N-(4-chlorobenzenesulphonyl)-N',S-dimethylisothiourea (5.40 g.) in acetonitrile was heated under reflux for 24 hours. Concentration, followed by recrystallisation from aqueous ethanol afforded N-(4-chlorobenzenesulphonyl)-N'-methyl-N"-[2-((4-methyl-5-imidazolyl)methylthio)ethyl]guanidine (4.6 g.), m.p. 153°-154°.

後処理

  1. temperatureunder reflux for 24 hours
  2. concentrationConcentration
  3. customfollowed by recrystallisation from aqueous ethanol

出典と根拠

ORDレコード
ord-15ba9b2cdf3042f8be979402501e9c75
出典データセット
uspto-grants-1978_04
特許番号
US04083988

反応ノート

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