2-Mercaptoethanol → HCID 21317600、化合物

HRID 2083285ノート

反応式

HRID 2083285 の反応式
[SH:1][CH2:2][CH2:3][OH:4].[Na].Br[CH:7]([CH2:19][CH2:20][CH2:21][CH:22]([O:28][C:29](=[O:31])[CH3:30])[CH2:23][CH2:24][CH2:25][CH2:26][CH3:27])[CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][C:14]([O:16][CH2:17][CH3:18])=[O:15]>CO>[OH:4][CH2:3][CH2:2][S:1][CH:7]([CH2:19][CH2:20][CH2:21][CH:22]([O:28][C:29](=[O:31])[CH3:30])[CH2:23][CH2:24][CH2:25][CH2:26][CH3:27])[CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][C:14]([O:16][CH2:17][CH3:18])=[O:15]

参加物

5

反応物 3

HCID 15672-MercaptoethanolHCID 5360545SodiumHCID 21317595Ethyl 8-bromo-12-acetoxyheptadecanoate

生成物 1

HCID 21317600HCID 21317600、化合物

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

2-Mercaptoethanol (31.2 g., 0.4 mole) is dissolved in a solution of sodium (9.2 g., 0.4 mole) in methanol (300 ml.). Ethyl 8-bromo-12-acetoxy-heptadecanoate (Example 1, Step E) (43.5 g., 0.1 mole) is added and the resulting solution is heated at feflux for 5 hours. Most of the methanol is then removed by evaporation in vacuo. Water (350 ml.) is added to the residue and the oily product taken up in ether, washed with water and brine and dried over sodium sulfate. Evaporation of the ether leaves the title compound as a yellow residual oil which is used in the next step without further purification.

後処理

  1. temperaturethe resulting solution is heated at feflux for 5 hours
  2. customMost of the methanol is then removed by evaporation in vacuo
  3. additionWater (350 ml.) is added to the residue
  4. washwashed with water and brine
  5. dry with materialdried over sodium sulfate
  6. customEvaporation of the ether

出典と根拠

ORDレコード
ord-fdeaa26349fa4138860b0fd9221fff04
出典データセット
uspto-grants-1978_04
特許番号
US04085125

反応ノート

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