2,3-Dihydroxybutanedioic Acid → 3-Methyl-5,6,7,8-tetrahydroquinoline-8-thiocarboxamide tartrate

HRID 2083424ノート

反応式

HRID 2083424 の反応式
[CH3:1][C:2]1[CH:3]=[N:4][C:5]2[CH:6]([C:12](=[S:14])[NH2:13])[CH2:7][CH2:8][CH2:9][C:10]=2[CH:11]=1.[C:15]([OH:24])(=[O:23])[CH:16]([CH:18]([C:20]([OH:22])=[O:21])[OH:19])[OH:17]>C(O)(C)C>[C:20]([CH:18]([CH:16]([C:15]([OH:24])=[O:23])[OH:17])[OH:19])([OH:22])=[O:21].[CH3:1][C:2]1[CH:3]=[N:4][C:5]2[CH:6]([C:12](=[S:14])[NH2:13])[CH2:7][CH2:8][CH2:9][C:10]=2[CH:11]=1

参加物

4

反応物 2

HCID 8752,3-Dihydroxybutanedioic AcidHCID 30039215,6,7,8-Tetrahydro-3-methyl-8-quinolinecarbothioamide

生成物 1

HCID 203583983-Methyl-5,6,7,8-tetrahydroquinoline-8-thiocarboxamide tartrate

試薬・触媒・溶媒 1

HCID 3776Isopropanol溶媒2 回

実験手順

To a solution of 3-methyl-5,6,7,8-tetrahydroquinoline-8-thiocarboxamide (13 g.) in hot isopropylalcohol (130 ml.) was added a solution of 9.5 g. tartaric acid in hot isopropylalcohol (65 ml.). The solution was filtered and allowed to cool. The precipitated crystals of the tartrate were removed by filtration, washed with a little cold isopropyl alcohol and dried. Yield 10.2g.m.p.158-160° C. Found: C, 50.56% H, 5.67%; N, 7.90%. Calc. for C15H20N2O6S : C, 50.55%, H, 5.65%; N, 7.86%.

後処理

  1. filtrationThe solution was filtered
  2. temperatureto cool
  3. customThe precipitated crystals of the tartrate were removed by filtration
  4. washwashed with a little cold isopropyl alcohol
  5. customdried

出典と根拠

ORDレコード
ord-3375ea8e930241dcb5482dc76abb477c
出典データセット
uspto-grants-1978_04
特許番号
US04085215

反応ノート

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