Iodoacetic Acid → (1-Oxo-2,2,3-trimethyl-6,7-dichloro-5-indanyloxy)acetic Acid

反応式

[CH3:1][C:2]1([CH3:16])[CH:10]([CH3:11])[C:9]2[C:4](=[C:5]([Cl:14])[C:6]([Cl:13])=[C:7]([OH:12])[CH:8]=2)[C:3]1=[O:15].I[CH2:18][C:19]([OH:21])=[O:20].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[O:15]=[C:3]1[C:4]2[C:9](=[CH:8][C:7]([O:12][CH2:18][C:19]([OH:21])=[O:20])=[C:6]([Cl:13])[C:5]=2[Cl:14])[CH:10]([CH3:11])[C:2]1([CH3:1])[CH3:16]

参加物

実験手順

A mixture of 2,2,3-trimethyl-5-hydroxy-6,7-dichloro-1-indanone (6.1 g., 0.025 mole), iodoacetic acid (5.58 g., 0.03 mole) and potassium carbonate (4.14 g., 0.03 mole) in acetone (80 ml.) is refluxed for 20 hours. The acetone is evaporated and the residue is dissolved in water and acidified with hydrochloric acid. The (1-oxo-2,2,3-trimethyl-6,7-dichloro-5-indanyloxy)acetic acid which separates is filtered, rinsed with water and dried.