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Sodium Carbonate → N-benzyl-N-(3,4-dibenzyloxybenzoyl)methyl-2-(4-carbamoylmethylphenoxy)ethylamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Carbonate | HCID 10340 | — |
| 反応物 | 3,4-Dibenzyloxyphenacyl bromide | HCID 12681802 | — |
| 反応物 | 4-(Benzylaminoethoxy)-phenylacetamide | HCID 18997242 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | N-benzyl-N-(3,4-dibenzyloxybenzoyl)methyl-2-(4-carbamoylmethylphenoxy)ethylamine | HCID 22750168 | — |
反応手順
A mixture 3,4-dibenzyloxyphenacyl bromide (32.8 g.), N-[2-(4-carbamoylmethylphenoxy)ethyl]benzylamine (22.8 g.), anhydrous sodium carbonate (8.4 g.) and ethanol (1 liter) was boiled under reflux for 3 hours, then filtered hot to remove the inorganic sediment and evaporated in vacuo to afford a thick syrup. The latter was crystallized upon trituration in diethyl ether and a sample of the resultant solid was recrystallized from ethanol to give N-benzyl-N-(3,4-dibenzyloxybenzoyl)methyl-2-(4-carbamoylmethylphenoxy)ethylamine, m.p. 99°-101° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04086272 |
| 出典データセット | uspto-grants-1978_04 |
| ORD ID | ord-04a432efd06f44e2a9d60ae5b3e21ffa |
| 出典メモ | uspto-grants-1978_04 |