Trifluoroacetic acid → HCID 131711089、化合物
反応式
C(OC([NH:8][C@H:9]([C:19]([OH:21])=[O:20])[CH2:10][O:11][CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)=O)(C)(C)C.[F:22][C:23]([F:28])([F:27])[C:24]([OH:26])=[O:25]>>[F:22][C:23]([F:28])([F:27])[C:24]([OH:26])=[O:25].[CH2:12]([O:11][CH2:10][C@@H:9]([C:19]([OH:21])=[O:20])[NH2:8])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1参加物
3
実験手順
Nα -t-Butoxycarbonyl-O-benzyl-L-serine, 5.0 g., is treated with 20 ml. of trifluoroacetic acid at 5° C. The solution is let stand at room temperature for 15 minutes and then the excess trifluoroacetic acid removed under reduced pressure. Benzene is added followed by evaporation. This process is repeated three times to remove excess trifluoroacetic acid. Finally the product is dried under reduced pressure and used without further treatment.
後処理
- addition, is treated with 20 ml
- customat 5° C
- customat room temperature
- customfor 15 minutes
- customthe excess trifluoroacetic acid removed under reduced pressure