Hydrazine hydrate (1:1) → HCID 178434196、化合物

HRID 2084290

反応式

HRID 2084290 の反応式
[C:1]([CH:4]1[C:9](=[O:10])[CH2:8][C:7]([CH3:12])([CH3:11])[CH2:6][C:5]1=O)(=O)[CH3:2].O.[NH2:15][NH2:16]>C(O)C>[CH3:2][C:1]1[C:4]2[C:9](=[O:10])[CH2:8][C:7]([CH3:12])([CH3:11])[CH2:6][C:5]=2[NH:16][N:15]=1

参加物

4

反応物 2

HCID 24654Hydrazine hydrate (1:1)HCID 5194481,3-Cyclohexanedione, 2-acetyl-5,5-dimethyl-

生成物 1

HCID 178434196HCID 178434196、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of 2-acetyl-5,5-dimethyl-cyclohexane-1,3-dione (2 g, 11.04 mmol), prepared as described in example 2, and hydrazine hydrate (1.66 ml, 33.13 mmol) in ethanol (25 ml) was stirred at room temperature for about 3 hours and then the solvent was evaporated. The residue was dissolved in dichloromethane, washed with water and brine, dried over sodium sulfate and evaporated. The title compound was obtained after chromatography on silica gel (dichloromethane:methanol=95:5) as a colourless solid (0.8 g, 45%): m.p. 103-104° C.

後処理

  1. customprepared
  2. customthe solvent was evaporated
  3. dissolutionThe residue was dissolved in dichloromethane
  4. washwashed with water and brine
  5. dry with materialdried over sodium sulfate
  6. customevaporated

出典と根拠

ORDレコード
ord-7341d36ebd6943d69784ba4eecbad69a
出典データセット
uspto-grants-2004_04
特許番号
US06716856B1

関連ノート

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