Bromotrimethylsilane → 1,5-Dibromo-2,3-dihydro-1H-indene
反応式
[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[CH:7](O)[CH2:6][CH2:5]2.[Br:12][Si](C)(C)C>C(Cl)(Cl)Cl>[Br:12][CH:7]1[C:8]2[C:4](=[CH:3][C:2]([Br:1])=[CH:10][CH:9]=2)[CH2:5][CH2:6]1参加物
4
実験手順
The compound obtained in Step A (70.19 mmol) is brought into solution in 420 ml of CHCl3, and bromotrimethylsilane (13.90 ml, 105.28 mmol, 1.5 eq.) is added at room temperature. The reaction mixture is stirred overnight at room temperature. The solvent and excess bromotrimethylsilane are removed by evaporation under reduced pressure. The oil is taken up in 150 ml of CHCl3, washed with 2×80 ml of water and 3×100 ml of saturated NaCl and dried over Na2SO4. The organic phase is then concentrated under reduced pressure to yield the title compound in the form of a brown oil.
後処理
- customThe solvent and excess bromotrimethylsilane are removed by evaporation under reduced pressure
- washwashed with 2×80 ml of water and 3×100 ml of saturated NaCl
- dry with materialdried over Na2SO4
- concentrationThe organic phase is then concentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-20974b9e15294dafbc8e34a64e6b255b
- 出典データセット
- uspto-grants-2004_04
- 特許番号
- US06716852B2
反応ノート
読み込み中…