3-Aminopyridine → 3-Amino-1-[4-(4-chlorophenyl)-2,5-dioxo-1H-pyrrol-3-yl]pyridinium chloride
反応式
[Cl:1][C:2]1[C:3](=[O:15])[NH:4][C:5](=[O:14])[C:6]=1[C:7]1[CH:12]=[CH:11][C:10]([Cl:13])=[CH:9][CH:8]=1.[NH2:16][C:17]1[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=1>C1COCC1>[Cl-:1].[NH2:16][C:17]1[CH:18]=[N+:19]([C:2]2[C:3](=[O:15])[NH:4][C:5](=[O:14])[C:6]=2[C:7]2[CH:12]=[CH:11][C:10]([Cl:13])=[CH:9][CH:8]=2)[CH:20]=[CH:21][CH:22]=1参加物
4
反応条件
- 温度
- 50 °C
実験手順
A mixture of 3-chloro-4-(4-chlorophenyl)-1H-pyrrole-2,5-dione (100 mg, 0.41 mmol) and 3-aminopyridine (42.7 mg, 0.45 mmol) in dry THF (2.5 mL) was heated at 50° C. for 2 hours then stirred at room temperature overnight. The resulting suspension was filtered and the solid washed with dichloromethane (20 mL), then hexane (10 mL) to give the title compound as a solid.