1,3-Propanediol → 4-(1,3,2-Dioxaborinan-2-yl)benzoic acid

HRID 2085743ノート

反応式

HRID 2085743 の反応式
[OH:1][B:2]([OH:12])[C:3]1[CH:11]=[CH:10][C:6]([C:7]([OH:9])=[O:8])=[CH:5][CH:4]=1.[CH2:13](O)[CH2:14][CH2:15]O>C1(C)C=CC=CC=1>[O:1]1[CH2:15][CH2:14][CH2:13][O:12][B:2]1[C:3]1[CH:11]=[CH:10][C:6]([C:7]([OH:9])=[O:8])=[CH:5][CH:4]=1

参加物

4

反応物 2

HCID 104421,3-PropanediolHCID 3121834-Carboxyphenylboronic Acid

生成物 1

HCID 145278654-(1,3,2-Dioxaborinan-2-yl)benzoic acid

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

A mixture of 4-(dihydroxyboryl)benzoic acid (30.00 g, 181 mmol) and 1,3-propanediol (15.20 g, 200 mmol) in toluene (750 mL) at 140° C. was stirred for 6 hours while collecting the water removed by azeotrope formation. The mixture was concentrated to provide the desired product.

後処理

  1. customwhile collecting the water
  2. customremoved by azeotrope formation
  3. concentrationThe mixture was concentrated

出典と根拠

ORDレコード
ord-1c9f953facd94e219498da73566bf0e1
出典データセット
uspto-grants-2004_04
特許番号
US06720338B2

反応ノート

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