HCID 22730718、化合物 → 1,1-Dimethylethyl N-[4-hydroxy-1-[(phenylthio)methyl]butyl]carbamate

HRID 2085782ノート

反応式

HRID 2085782 の反応式
[C:1]([O:5][C:6]([NH:8][CH:9]([CH2:16][S:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[CH2:10][CH2:11][C:12](OC)=[O:13])=[O:7])([CH3:4])([CH3:3])[CH3:2].C([BH-](CC)CC)C.[Li+]>C1COCC1>[OH:13][CH2:12][CH2:11][CH2:10][CH:9]([NH:8][C:6](=[O:7])[O:5][C:1]([CH3:3])([CH3:2])[CH3:4])[CH2:16][S:17][C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1

参加物

4

反応物 2

HCID 22730718HCID 22730718、化合物HCID 23664628Lithiumtriethylborohydride

生成物 1

HCID 227307071,1-Dimethylethyl N-[4-hydroxy-1-[(phenylthio)methyl]butyl]carbamate

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

実験手順

A solution of Example 384B (538 mg, 1.6 mmol) in THF (4 mL) at −50° C. was treated with 1M lithium triethylborohydride in THF (4 mL), stirred for 1 hour, poured into ice (˜15 g), and extracted with ethyl acetate (100 mL). The extract was washed with water (20 mL) and brine (10 mL), dried (MgSO4), filtered, and concentrated to provide the desired product of sufficient purity for subsequent use.

後処理

  1. extractionextracted with ethyl acetate (100 mL)
  2. washThe extract was washed with water (20 mL) and brine (10 mL)
  3. dry with materialdried (MgSO4)
  4. filtrationfiltered
  5. concentrationconcentrated

出典と根拠

ORDレコード
ord-8ce9b80608d64ef19872ac2099399ff0
出典データセット
uspto-grants-2004_04
特許番号
US06720338B2

反応ノート

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