HCID 22727258、化合物 → Tert-butyl 3-methyl-5-oxopiperazine-1-carboxylate
反応式
C(OC([NH:11][CH:12]([CH3:28])[CH2:13][N:14]([C:21]([O:23][C:24]([CH3:27])([CH3:26])[CH3:25])=[O:22])[CH2:15][C:16](OCC)=[O:17])=O)C1C=CC=CC=1>CO.[Pd]>[CH3:28][CH:12]1[NH:11][C:16](=[O:17])[CH2:15][N:14]([C:21]([O:23][C:24]([CH3:27])([CH3:26])[CH3:25])=[O:22])[CH2:13]1参加物
4
反応条件
- 温度
- 50 °C
実験手順
A solution of ethyl 2-[[2-[[(benzyloxy)carbonyl]amino]propyl](tert-butoxycarbonyl)amino]acetate (2.3 g) and 10% Pd/C (0.23 g) in methanol (46 ml) was stirred at room temperature for 1 hour under a hydrogen atmosphere. The catalyst was filtered off and the filtrate was stirred at 50° C. for 1 hour, concentrated under reduced pressure to obtain the title compound (1.1 g) as a colorless non-crystalline powder.
後処理
- filtrationThe catalyst was filtered off
- concentrationconcentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-7854e78de5cf40eab719b63086ad7a40
- 出典データセット
- uspto-grants-2004_04
- 特許番号
- US06723722B1
反応ノート
読み込み中…