Sodium borohydride → (4-Chloro-6-methylpyridin-2-yl)methanol

HRID 2086261ノート

反応式

HRID 2086261 の反応式
[Cl:1][C:2]1[CH:7]=[C:6]([CH3:8])[N:5]=[C:4]([C:9](OCC)=[O:10])[CH:3]=1.[BH4-].[Na+]>CO>[Cl:1][C:2]1[CH:7]=[C:6]([CH3:8])[N:5]=[C:4]([CH2:9][OH:10])[CH:3]=1

参加物

4

反応物 2

HCID 4311764Sodium borohydrideHCID 22727099Ethyl 4-chloro-6-methylpyridine-2-carboxylate

生成物 1

HCID 22727138(4-Chloro-6-methylpyridin-2-yl)methanol収率 95%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A solution of ethyl 4-chloro-6-methylpyridine-2-carboxylate (0.80 g) in methanol (30 ml) was treated at room temperature portionwise with sodium borohydride (1.51 g) and the reaction mixture was heated under reflux for 2 hours. The reaction mixture was concentrated and the resultant residue was combined with water and ethyl acetate, and the organic phase was isolated, dried and concentrated to obtain the title compound (0.60 g) as a tan powder.

後処理

  1. temperaturethe reaction mixture was heated
  2. temperatureunder reflux for 2 hours
  3. concentrationThe reaction mixture was concentrated
  4. customthe organic phase was isolated
  5. customdried
  6. concentrationconcentrated

出典と根拠

ORDレコード
ord-9fbab4c950f7460da320124c38b87706
出典データセット
uspto-grants-2004_04
特許番号
US06723722B1

反応ノート

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