3,4-Dichlorobenzaldehyde → 5-[(3,4-Dichlorophenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one
反応式
[S:1]1[CH2:7][C:5](=[O:6])[NH:4][C:2]1=[S:3].[Cl:8][C:9]1[CH:10]=[C:11]([CH:14]=[CH:15][C:16]=1[Cl:17])[CH:12]=O.C([O-])(=O)C.[Na+]>CO>[Cl:8][C:9]1[CH:10]=[C:11]([CH:12]=[C:7]2[S:1][C:2](=[S:3])[NH:4][C:5]2=[O:6])[CH:14]=[CH:15][C:16]=1[Cl:17]参加物
5
反応条件
- 温度
- 65 °C
実験手順
A 50 mL flask was charged with 899 mg rhodanine (6.75 mmol, 1.0 equiv), 1.77 g 3,4-dichlorobenzaldehyde (10.1 mmol, 1.5 equiv), 1.66 g sodium acetate (20.25 mmol, 3.0 equiv) and 20 mL methanol. The mixture was heated to 65° C. with stirring for 1.75 h. The yellow solid was then filtered and washed (4×MeOH) to give the product 5-(3,4-dichlorophenylmethylene)-4-oxo-2-thionothiazolidine as a yellow solid (1.059 g 3.67 mmol, 54%).
後処理
- filtrationThe yellow solid was then filtered
- washwashed (4×MeOH)
出典と根拠
- ORDレコード
- ord-8493600ae1e948e4b9d8a506781b9b84
- 出典データセット
- uspto-grants-2004_04
- 特許番号
- US06727267B2
反応ノート
読み込み中…