4-Bromophenacyl bromide → N-[4-(4-Bromo-phenyl)-1H-imidazol-2-yl]-acetamide

HRID 20885

反応式

HRID 20885 の反応式
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([Br:11])=[CH:7][CH:6]=1)=O.[C:12]([NH:15][C:16]([NH2:18])=[NH:17])(=[O:14])[CH3:13]>CN(C=O)C>[Br:11][C:8]1[CH:9]=[CH:10][C:5]([C:3]2[NH:18][C:16]([NH:15][C:12](=[O:14])[CH3:13])=[N:17][CH:2]=2)=[CH:6][CH:7]=1

参加物

4

反応物 2

HCID 74544-Bromophenacyl bromideHCID 178475102HCID 178475102、化合物

生成物 1

HCID 10468856N-[4-(4-Bromo-phenyl)-1H-imidazol-2-yl]-acetamide

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

A mixture of 2-bromo-1-(4-bromophenyl)ethanone (2.00 g, 7.20 mmol) and acetylguanidine (2.18 g, 21.6 mmol) in DMF (40 mL) was stirred at rt for 48 h. The solution was concentrated to dryness in vacuo and the resulting brown solid was of sufficient purity for use in the next step. LCMS: Anal. Calcd. for C11H10BrN3O: 279, 281; found: 280, 282 (M+H)+.

後処理

  1. concentrationThe solution was concentrated to dryness in vacuo

出典と根拠

ORDレコード
ord-9095334553934822abb0be22ce7699c7
出典データセット
uspto-grants-2010_06
特許番号
US07745636B2

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