Trifluoroacetic acid → HCID 86635024、化合物

反応式

Cl.Cl.NCCNC1C=CC(C#N)=CN=1.C(OC(=O)[NH:21][CH2:22][CH2:23][NH:24][C:25]1[S:26][C:27]([C:31]#[N:32])=[C:28]([NH2:30])[N:29]=1)(C)(C)C.[F:34][C:35]([F:40])([F:39])[C:36]([OH:38])=[O:37]>>[F:34][C:35]([F:40])([F:39])[C:36]([OH:38])=[O:37].[NH2:30][C:28]1[N:29]=[C:25]([NH:24][CH2:23][CH2:22][NH2:21])[S:26][C:27]=1[C:31]#[N:32]

参加物

反応物 3

HCID 6422Trifluoroacetic acid

HCID 57911749tert-Butyl{2-[(4-amino-5-cyano-1,3-thiazol-2-yl)amino]ethyl}carbamate

HCID 669113296-[(2-Aminoethyl)amino]nicotinonitrile dihydrochloride

生成物 1

HCID 86635024HCID 86635024、化合物

実験手順

Analogously to the preparation of the cyanopyridine (Example 2A), 130 mg (0.46 mmol) of the Boc-protected amine (Example 15A) and 1.05 g (9.18 mmol) of trifluoroacetic acid gave, after removal of all volatile components, 130 mg (96% of theory) of the product.