Water → 5-Bromo-3-chloro-4-methyl-1H-pyrrolo[2,3-b]pyridine

HRID 2088972ノート

反応式

HRID 2088972 の反応式
[Br:1][C:2]1[C:3]([CH3:11])=[C:4]2[CH:10]=[CH:9][NH:8][C:5]2=[N:6][CH:7]=1.[Cl:12]N1C(=O)CCC1=O.O>O1CCCC1>[Br:1][C:2]1[C:3]([CH3:11])=[C:4]2[C:10]([Cl:12])=[CH:9][NH:8][C:5]2=[N:6][CH:7]=1

参加物

5

反応物 3

HCID 962WaterHCID 31398ChlorosuccinimideHCID 401522575-bromo-4-methyl-1H-pyrrolo[2,3-b]pyridine

生成物 1

HCID 534129335-Bromo-3-chloro-4-methyl-1H-pyrrolo[2,3-b]pyridine収率 96.9%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

The compound obtained in Step 3 of Example 36 (323 mg) was dissolved in tetrahydrofuran (6 ml). N-Chlorosuccinimide (225 mg) was added and the mixture was stirred at room temperature for three days. Water was added to the reaction solution, followed by extraction with chloroform. The organic layer was dried over anhydrous sodium sulfate, and the solvent was evaporated to give the title compound (364 mg).

後処理

  1. extractionfollowed by extraction with chloroform
  2. dry with materialThe organic layer was dried over anhydrous sodium sulfate
  3. customthe solvent was evaporated

出典と根拠

ORDレコード
ord-58a52b4aa75a439eba2f2414f9bf642e
出典データセット
uspto-grants-2013_05
特許番号
US08436012B2

反応ノート

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