Ammonia → 5-(Aminomethyl)-1H-indazole
反応式
[NH:1]1[C:9]2[C:4](=[CH:5][C:6]([C:10]#[N:11])=[CH:7][CH:8]=2)[CH:3]=[N:2]1.N.[H][H]>C1COCC1.CO.[Ni]>[NH:1]1[C:9]2[C:4](=[CH:5][C:6]([CH2:10][NH2:11])=[CH:7][CH:8]=2)[CH:3]=[N:2]1参加物
7
実験手順
To a suspension of 1H-indazole-5-carbonitrile (0.235 g, 1.64 mmol) in THF (6 mL) was added 2 mL of 2 N ammonia in methanol and the flask was charged with 0.05 g Raney® 2800 nickel. A hydrogen balloon was attached to the flask and the system was purged 3 times with hydrogen. After stirring vigorously overnight the reaction mixture was diluted with methanol and filtered through a pad of celite. The solvent was evaporated in vacuo to provide 1-(1H-indazole-5-yl)methanamine.
後処理
- customthe system was purged 3 times with hydrogen
- additionwas diluted with methanol
- filtrationfiltered through a pad of celite
- customThe solvent was evaporated in vacuo
出典と根拠
- ORDレコード
- ord-1219f384a4d142bdb185821b5e1b19a3
- 出典データセット
- uspto-grants-2013_05
- 特許番号
- US08436016B2
反応ノート
読み込み中…