Sodium Hydroxide → HCID 178493708、化合物
反応式
[Cl:1][C:2]1[N:7]=[C:6]([NH:8][C@H:9]2[CH2:14][CH2:13][C@H:12]([NH:15][C:16](=[O:22])[O:17][C:18]([CH3:21])([CH3:20])[CH3:19])[CH2:11][CH2:10]2)[CH:5]=[C:4]([C:23]2[C:31]3[C:26](=[N:27][CH:28]=[C:29]([O:32][CH3:33])[CH:30]=3)[N:25](S(C3C=CC=CC=3)(=O)=O)[CH:24]=2)[CH:3]=1.[OH-].[Na+]>O1CCOCC1>[Cl:1][C:2]1[N:7]=[C:6]([NH:8][C@H:9]2[CH2:14][CH2:13][C@H:12]([NH:15][C:16](=[O:22])[O:17][C:18]([CH3:20])([CH3:21])[CH3:19])[CH2:11][CH2:10]2)[CH:5]=[C:4]([C:23]2[C:31]3[C:26](=[N:27][CH:28]=[C:29]([O:32][CH3:33])[CH:30]=3)[NH:25][CH:24]=2)[CH:3]=1参加物
4
反応条件
- 温度
- 100 °C
実験手順
A solution of Example 213d (0.500 g, 0.817 mmol) in dioxane (3.0 mL) was treated with 20% NaOH. The reaction mixture was heated at 100° C. for an hour. The solvent was evaporated and the residue was treated with water, sonicated, filtered, washed with water again, and oven-dried to give 0.289 g (75%) of the title compound.