N-Iodosuccinimide → methyl 3-iodo-1H-pyrrolo[2,3-b]pyridine-5-carboxylate
反応式
[CH3:1][O:2][C:3]([C:5]1[CH:6]=[C:7]2[CH:13]=[CH:12][NH:11][C:8]2=[N:9][CH:10]=1)=[O:4].[I:14]N1C(=O)CCC1=O>CN(C=O)C>[CH3:1][O:2][C:3]([C:5]1[CH:6]=[C:7]2[C:13]([I:14])=[CH:12][NH:11][C:8]2=[N:9][CH:10]=1)=[O:4]参加物
4
実験手順
To a solution of Example 235a (1.04 g, 5.9 mmol) in 12 mL anhydrous DMF was added N-iodosuccinimide (1.46 g, 6.49 mmol) and the solution stirred at room temperature for 16 hours. The solvent was evaporated and the residue suspended in water and filtered. The collected solid was triturated with dichloromethane and the mixture filtered. The dichloromethane filtrate was concentrated to a brown powder that was carried on without purification.
後処理
- customThe solvent was evaporated
- filtrationfiltered
- customThe collected solid was triturated with dichloromethane
- filtrationthe mixture filtered
- concentrationThe dichloromethane filtrate was concentrated to a brown powder that
- customwas carried on without purification
出典と根拠
- ORDレコード
- ord-88e56c279d2b41248560f24fea579364
- 出典データセット
- uspto-grants-2013_05
- 特許番号
- US08435980B2
反応ノート
読み込み中…